DNA Free

The free radicals are produced all the moment in the organism, physiological participate of reactions biochemists (electron transference). Essential structures for the cell as the lipdeos, proteins, acid desoxirribonuclico (DNA) and acid ribonucleic (RNA) comumente are attacked by the free radicals. This is a factor for the sprouting of patologias (CAETANO, 2009). The lipdica peroxidao also is caused by the exacerbado alcoholic beverage use. Etanol increases the production of free radicals and diminishes the concentration of Glutadiona Total (GSH).

The GSH is a protective agent of the mucosa, which had its antirust activity (ROZZA, 2009). Experimental studies are standed out involving the absolute induction of ulcer for etanol in animals of laboratory, where if it observed great release of free radicals, exceeding the antirust capacity of the cell. With this estresse it occurs it oxidativo, taking the injury of the cellular membranes, DNA and also reduction of the gastric protectors as the not-proteinic sulfidrilicos groupings (SHs) of the gastric cells (BONAMIN, 2010). . the B. Figure 3: .

The Photo of a stomach of rat without ulcerativa injury. B. Photo of a stomach of rat with ulcerativa injury (BONAMIN, 2010) Other harmful factors as the nicotine can after affect the gastric protection when hindering the neutralization of acid the feeding. This makes with that the fabric gastric is for a bigger period in contact with the gastric juice lesionando it (PACHECO, 2009). The use drawn out of antiinflammatory not esteroidais (AINES) inhibits the enzyme that catalyzes the reaction of acid araquidnico in Prostaglandins, cicloxigenase 1 (COX-1). The Prostaglandins vasodilatadoras and citoprotetoras must different the mechanisms protectors. The AINES still inhibit cicloxigenase 2 (COX-2), that it is the related enzyme the inflammatory processes (MILK, 2004). An important pointer of the peptic ulcer is hematmese (extravasation of blood of the gastrintestinal system) beyond other clinical symptoms as intense pain in the abdomen and vomit (al HISSES et., 2005).

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